Chronic nephritis is the most common disease in nephrology, which clinically manifests as hematuria, proteinuria, edema, hypertension, and can be accompanied by varying degrees of renal hypoplasia. For the treatment of chronic nephritis, the focus is on assessing the severity of renal disease. In the early stage of kidney disease, ACEI or ARB drugs can be applied to control blood pressure and reduce urinary protein, representing drugs such as Irbesartan, Valsartan, Benadryl, etc., and oral Pepcid capsules can also be taken to protect the kidneys. If the quantitative amount of urine protein is very large, more than 3.5g, then we need to do renal puncture to clarify the specific type of pathology, and choose hormone or immunosuppressant treatment. When creatinine is elevated, urethane granules can be applied to reduce creatinine treatment. At the same time, it is also necessary to control blood glucose, blood pressure, blood lipids and low-salt, low-fat, high-quality protein diet as the principle, through the integrated treatment of kidney disease, to slow down the deterioration of renal function. Once the disease progresses to uremia stage, regular dialysis treatment is needed.