Hepatitis B e antigen 260 PEI/L is not normal. Hepatitis B e antigen, abbreviated as HBeAg, is a structural protein within the nucleus of the hepatitis B virus and is a marker of early infection with the hepatitis B virus. HBeAg is one of the main reference indicators to determine the replication of the hepatitis B virus and the strength of the infectiousness of its normal value is 0~0.5PEI/L, more than 0.5PEI/L is a positive result, suggesting that the replication of the hepatitis B virus is active hepatitis B is in the active stage of strong infectiousness, if the hepatitis B surface antigen and hepatitis B core antibody is also positive, it is hepatitis B triple positive, with a strong infectiousness. Hepatitis B triple positive should be rechecked on time for HBV DNA, liver function, two half pairs and ultrasound test, etc. Oral antiviral drugs (such as entecavir, etc.) should be taken under the guidance of doctors to inhibit viral replication, reduce liver damage and prevent further progression of the disease if necessary. If Hepatitis B e antigen 260 PEI/L is detected, it is recommended to consult a doctor promptly.