Fever is a common symptom of most diseases in pediatrics. Fever can lead to discomfort such as depression, increased heart rate and loss of appetite; in severe cases, it can even lead to high fever convulsions. A child with a high fever that does not go away also usually makes mothers anxious and travel to and from the hospital every day. When the body temperature reaches 38.5℃ or more, oral antipyretics are needed. Commonly used antipyretics include acetaminophen suspension, ibuprofen dry suspension, and pediatric aminophenanthramine pellets. Acetaminophen suspension, used for fever caused by pediatric common cold or influenza, children with persistent high fever can usually repeat the medication once at an interval of 4-6 hours, and it should be noted that no more than 4 times in 24 hours. Ibuprofen suspension is used to relieve mild to moderate pain such as headache, joint pain, migraine, toothache, muscle pain, neuralgia, dysmenorrhea. It is also used for fever caused by the common cold or influenza. For children with persistent high fever, the medication can usually be repeated once at an interval of 4-6 hours, and it is important to note that no more than 4 times in 24 hours. For children with persistent high fever, the medication can be repeated once at an interval of 8 hours, and it should be noted that it should not be used more than 3 times in a 24-hour period. The above mentioned drugs should not be used to reduce fever for more than 3 days, and if the symptoms are not relieved, you need to consult your physician or pharmacist. Children should not be given an overdose of antipyretic drugs. For fevers of unclear etiology, it is imperative to actively treat the fever while carefully observing the changes in the child’s systemic symptoms and providing the doctor with clear and reliable medical history so that the cause can be found and treated as soon as possible.