Generally children with fever over 38.5℃ need to take antipyretic drugs. The commonly used antipyretic drugs are acetaminophen suspension, ibuprofen dry suspension, and pediatric aminophen xanthamine granules. What are the effects of antipyretic drugs for children? Acetaminophen suspension is used for fever caused by pediatric common cold or influenza, and also for the relief of mild to moderate pain, such as joint pain, migraine, headache, muscle pain, neuralgia, and toothache. Acetaminophen is an antipyretic and analgesic over-the-counter drug, which is used to relieve fever by inhibiting the enzyme cyclooxygenase and selectively inhibiting the synthesis of prostaglandins in the hypothalamic thermoregulatory center, resulting in peripheral vasodilation and sweating. Ibuprofen suspension is used for the relief of mild to moderate pain such as headache, arthralgia, migraine, toothache, muscle pain, neuralgia, and dysmenorrhea. It is also used for fever caused by common cold or influenza. Ibuprofen is a non-steroidal anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic effects. Ibuprofen achieves its antipyretic effect by inhibiting the production of prostaglandin E in the anterior hypothalamus, and it also stimulates the body to produce endogenous “cooling source”. Ibuprofen has a fast onset of action and the body temperature drops significantly after 1 hour, and it also has anti-infective effects. In pediatric aminophenanthrene granules, acetaminophen can inhibit prostaglandin synthesis, leading to peripheral vasodilation, sweating, antipyretic and analgesic effect; chlorpheniramine maleate is an antihistamine, anti-capillary dilation due to allergic reactions, can reduce capillary permeability, relieve bronchial smooth muscle contraction, can reduce runny nose, congestion, sneezing and other symptoms; artificial cowberry has an antipyretic and analgesic effect.