Studies have shown that violent killings of loved ones by schizophrenic patients occur with serious consequences. Everyone should clarify their clinical characteristics, influencing factors and treatment prognosis, which can help prevent this type of behavior. A survey study of violent killing of relatives in an urban area showed that 86% of them were male and 14% were female; the average age was 35 years old; 65% were middle school educated, 14% were below elementary school, and 21% were above high school; 33% were unmarried, 28% were married, and 39% were widowed. Among them, middle-aged middle-school educated widowed male schizophrenic patients were most likely to produce violent parental killing behavior. Further analysis of the reasons for killing relatives, unprovoked killing accounted for 71%, followed by poor care accounted for 18%, quarrels accounted for 6%, and bullying accounted for 5%; 71% occurred during the day; 89% occurred at home; the objects of killing relatives were spouses 41%, parents 39%, relatives 16%, and children 4%; the consequences were, killing resulting in 90% death and 10% injury. This group of schizophrenic patients was characterized by a duration of more than 1 year in 93%, 1-5 years in 42%, 5-10 years in 23%, and 10 years in more than 29%; more than 1 hospitalization in 98%; history of previous violence in 65%; clinical typing paranoid type in 57%, mixed type in 33%, adolescent type in 7%, and simple type in 3%. Psychiatric symptoms leading to violence were delusions of victimization 43%, conduct disorder 30%, jealousy delusions 21%, and hallucinations 6%. For patients with schizophrenia, it is important to strengthen safety supervision. Patients are prone to treat their relatives as objects of venting and attack, and once their delusions of victimization and jealousy appear, patients lose their sanity and affection, and even develop delusions of non-blood relatives, for example, not recognizing their parents as their biological parents, or even suspecting that their parents will poison the food they cook. Family members must pay attention to the ways and means of caring for the patient and try to avoid conflicts and arguments with the schizophrenic. The killing of relatives occurs mostly during the day and in the home, which is different from the premeditated behavior of normal crime. Studies have shown that schizophrenic patients need not only full treatment, but also stronger social supervision and regular review and assessment of their condition to avoid harmful behaviors such as violent parental killing. For patients with severe schizophrenia, minimally invasive neuromodulation surgery can be performed with the consent of the guardian. Immediately after surgery, the patient’s relational hostility and violent behavior disappears, and various positive psychiatric symptoms are effectively controlled, which can have an auxiliary effect on family safety and social harmony. Experts suggest that early treatment is crucial for seriously ill patients.