Why do thin people also get gallstones? The development of gallbladder stones is multifactorial. Bile is a complex system of water-containing colloids that are essential for carrying out normal physiological functions, including lipid excretion. Bile is formed primarily in the capillary bile ducts of the liver, which are small (1-2 microns) spaces formed at the tight junctions of hepatocytes. Bile is a complex formed by water, electrolytes, and a variety of lipid solutes, including bile salts, phospholipids (>96% mixed lecithin), and cholesterol, as well as proteins with bound bilirubin. Phospholipids and bile salts dissolve cholesterol in an aqueous solution to facilitate the flow of bile from the biliary system into the digestive tract. In healthy individuals, about half of the bile secreted is stored in the gallbladder during the interdigestive period, concentrated, and slightly acidified. Changes in the relative or absolute ratio of cholesterol, phospholipids, and bile salts result in cholesterol supersaturation and separation of cholesterol from the bile solution. The most common change is the secretion of excess cholesterol by the liver. Excess cholesterol forms monolayers with biliary phospholipids. Under proper physicochemical conditions, these monolayers can aggregate to form multilayers, which eventually leak out as cholesterol hydrate crystals and collect in the gallbladder. When these crystals aggregate with the mucus gel secreted by the gallbladder, they form gallbladder cholesterol stones. Most cholesterol stones are formed in the gallbladder. In rare cases, such as inherited defects in biliary phospholipid secretion, stones can form anywhere in the bile duct. Obese people have a higher chance of suffering from high cholesterol, the so-called metabolic syndrome. Naturally, the cholesterol excreted in the bile is also relatively high, so people with metabolic syndrome have a higher chance of developing gallstones. Statistics show that people with metabolic syndrome are about four times more likely to develop gallstones than those without metabolic syndrome. Then why do thin people also get gallstones? The general reasons are as follows: 1. Because of the sudden weight loss, a large amount of stored cholesterol in the body is concentrated from the bile, making the concentration of cholesterol in the bile suddenly increase and precipitate into gallstones. Therefore, weight loss should also be done slowly. 2, inflammation caused by bacterial or viral infection in the gallbladder is also a cause of gallstones. Most commonly, Helicobacter pylori infection may be the starting cause of some gallstones. Therefore, epigastric discomfort should be checked for Helicobacter pylori. If there is an infection to be removed promptly. 3, the bile in the gallbladder is constantly updated. When not eating the bile produced by the liver hide is stored in the gallbladder and slowly concentrated. When eating the gallbladder empties and mixes the bile with food to help digestion. The emptied gallbladder will collect the bile produced by the liver again for reuse at the next meal. If you skip breakfast for a long time, then the concentrated bile is not discharged at night for a long time and over time small deposits build up into stones. Therefore, skipping breakfast is not a good habit. In addition, long-term non-eating, with intravenous nutrition of seriously ill patients will also have bile stasis, complicating gallstones. 4, we also often see that the abnormal structure of the gallbladder is not conducive to normal gallbladder emptying, and over time small precipitates accumulate into stones. This condition is also generally not suitable for treatment by gallbladder stone extraction. 5. Some drugs can also induce gallbladder stones. For example, long-term use of ceftriaxone can cause bile depression and complicate stones. Therapeutic use of growth inhibitors and their analogs can also inhibit gallbladder emptying and induce stones. Therefore, patients with such drugs should be mainly complicated by gallstones. 6, many genetic diseases often combined with gallstones, such as Gaucher’s disease, thalassemia, growth inhibitors produce more syndromes and diseases, can make changes in the composition of bile in the gallbladder, lipid or bilirubin too high, or gallbladder emptying disorders cause gallstones. In this case, treatment of gallstones is only an indicator that the primary disease should be treated carefully.