Many commonly used drugs can cause blood glucose abnormalities, either in the form of elevated blood glucose or the occurrence of hypoglycemia. Drug-induced blood glucose abnormalities have a common feature, that is, blood glucose can usually return to normal or be significantly improved after discontinuing the triggering drug. Drug-induced glucose abnormalities mainly act on two links: one is to inhibit insulin synthesis and secretion; the other is to increase insulin resistance. The drugs that may inhibit insulin synthesis and secretion are: 1. Immunosuppressants: Tacrolimus and cyclosporine A are used to prevent rejection after organ transplantation. 2, thiazide diuretics: common ones such as hydrochlorothiazide, which has direct toxicity to pancreatic β-cells, but also stimulates α-cells and promotes the secretion of hyperglycemia. In addition, the side effect of the drug hypokalemia is more likely to inhibit insulin secretion. 3, calcium channel blockers: such as verapamil. Inhibits insulin secretion and is dose-dependent. 4, beta-blockers: can inhibit the secretion and release of insulin, and in severe cases can induce diabetic hyperosmolar coma. The stronger the lipophilicity of these drugs, the lower the selectivity to β-receptors, the stronger the inhibition of insulin, and the more likely to lead to hyperglycemia. 5, β-receptor stimulants: Although these drugs can increase the secretion of insulin, but at the same time increase the decomposition of liver glycogen and fat. For example, high-dose sedative injection of salbutamol can lead to diabetic ketoacidosis. Drugs that may increase insulin resistance, more typically glucocorticoids, research has confirmed that prolonged application of glucocorticoids, whether intravenous, oral, or topical, may lead to increased blood glucose in diabetic patients, or lead to steroidal diabetes in people with normal blood glucose. Other drugs are: antipsychotics, niacin, alpha-interferon, and oral contraceptives. In addition, other drugs that can induce hyperglycemia are: gatifloxacin, phenytoin sodium, thyroid hormone, lithium, levodopa, theophylline, isoniazid, acetazolamide, morphine, rifampin, anti-inflammatory pain, and octreotide.