Difference between allergic rhinitis and allergic rhinitis

  In 1990, the European Academy of Allergology and Clinical Immunology (EAACI) established a working group to standardize the terminology of allergic reactions, based on the inconsistent use of terms in the field of allergic reactions. The NPS defines the terms hypersensitivity, atopy, allergy, and allergen, as well as the nomenclature of some allergic diseases, based on a review of the history of the development of allergology. After several years of application, the NPS has been widely accepted, with more than 10 languages in the literature and 24 languages on the EAACI website using the NPS nomenclature, and WAO has given full recognition to the EAACI NPS and published an official document in 2004 – Global Application of Revised Nomenclature for Allergic Reactions (Revised nomenclature for allergy for global use: report of the nomenclature review Committee of the World Allergy Organization). The paper states that nomenclature revisions should be based on the mechanism that triggers the reaction. Because very similar inflammatory reactions and clinical manifestations can be triggered by different mechanisms, proper nomenclature is important for researchers, clinicians, and patients to understand the mechanisms and nature of the disease, as failure to do so may lead to inappropriate conclusions, inappropriate preventive recommendations, and poor treatment outcomes.      These two documents define allergy and allergic reactions as follows: hypersensitivity is a condition in which a normal person can tolerate a definite stimulus in a certain dose, but in that individual can trigger objectively reproducible signs and symptoms. Due to the nature of the stimulus (physical, chemical, biological or a pollutant), the mechanisms of allergy are very different and can be broadly divided into immunological and non-immunological mechanisms. Allergic reaction (allergy) is an allergic reaction triggered by a specific immunological mechanism. It can be mediated by antibodies or cells. In general, the antibody that mediates allergic reactions is IgE, often called IgE-mediated allergic reactions, while the substance that induces immune cells to produce specific IgE is called allergen, which is mainly protein-based. Recent findings suggest that non-IgE-mediated allergic reactions may also exist. In addition, atopy generally refers to the tendency of individuals or families to produce IgE specific to common allergens, reflecting certain genetic traits. However, patients with allergic rhinitis are not necessarily atopic individuals.  It is worth mentioning here that the current textbook on immunology in China translates hypersensitivity as hypersensitivity reaction, while the IgE-mediated type I hypersensitivity reaction is called tachyphylaxis, and the resulting disease is called allergic disease.  From the above, we can see that allergy refers to various abnormal reactions that occur unexpectedly, including allergic reactions, but is not exactly the same as allergic reactions. Allergy should be seen as a term that covers both allergic and non-allergic reactions.  One of the basic principles of translating scientific terms is that the translation should be most easily understood and accepted by the reader. Accordingly, it is correct to translate allergic rhinitis as allergic rhinitis, which reflects the appearance of rhinitis, meaning that the individual overreacts to certain stimuli that can be tolerated by normal people. However, another principle of scientific term translation is that the scientific connotation of the term should be preserved. Although the term allergic rhinitis also contains some scientific connotation, the mechanisms covered are complex and mostly unclear to date. In contrast, the general framework of the pathogenesis of IgE-mediated allergic inflammation is largely clear, so the nomenclature of allergic rhinitis reflects the nature of the disease more correctly.  Finally, we must mention the pioneer and pioneer of clinical allergology in China, Professor Zhang Qingsong, an otorhinolaryngologist, who first translated allergic rhinitis as allergic rhinitis in his article on allergic rhinitis and sinusitis published in the inaugural issue of this journal in 1953. Although the understanding of the mechanism of allergic rhinitis was much less than today, Prof. Zhang Qingsong’s translation of allergic rhinitis as allergic rhinitis based on his profound knowledge of allergic rhinitis seems to be very appropriate nowadays, which makes us feel a sense of admiration for Prof. Zhang.