Glutathione has a therapeutic effect on insomnia, but there are clear indications. Insomnia is an end result of multiple complex factors, including alterations in various physiological, psychological, and environmental factors, as well as medications, neuropsychiatric and somatic disorders. Common causes include family genetic factors, stress and life events, lifestyle problems, self-characteristic personality, previous illnesses taking certain specific medications, and advanced age in women. The treatment of insomnia includes psychotherapy, medication, physical therapy, acupuncture, massage therapy and bath therapy, biofeedback therapy, diversion therapy, cognitive therapy, behavioral therapy, hypnotherapy, Chinese medicine therapy and integrated therapy. Bad sleep behaviors and concepts should be prevented and corrected first, and the triggering factors of insomnia should be dealt with, supplemented by medication if necessary. Glutamate is a ferulic acid ester mixture, which can adjust the function of plant nerves and reduce the endocrine balance disorder, and also has a certain improvement effect on the symptoms of psychoneurological disorders, and can be used clinically as a sedative and sleep aid, as an adjunctive treatment for neurosis, and has a certain therapeutic effect on neurasthenia. Glutathione toxic side effects are small, relatively safe to take, there is no restriction on age, but overdose or prolonged use of this product may sometimes appear some adverse reactions, such as nausea, vomiting, rash, excessive oil secretion, etc., can slowly disappear after stopping the drug, so do not take the process of increasing the dosage without authorization, if necessary, should go to a regular hospital for further consultation and treatment. Therefore, for patients with insomnia caused by neurasthenia, glutathione has a certain therapeutic effect, but it should also be noted that it should not be abused to avoid adverse reactions.