Esophageal leukoplakia can be improved by using domperidone and magnesium aluminum carbonate for bile reflux, and surgical treatment can be used if necessary. The appearance of esophageal white spots is mainly due to bile reflux, gastric acid causes damage to the protective barrier of the esophageal mucosa, inducing esophagitis disease and caused, in the treatment of the primary disease needs to be treated. Domperidone can promote gastric peristalsis and improve the symptoms of indigestion, and when the food in the stomach is digested, the acid reflux phenomenon can be reduced. Magnesium aluminum carbonate can not only inhibit the secretion of gastric acid, but also protect the gastric mucosa, which can help the esophageal mucosa to recover as soon as possible after taking it, and also has a therapeutic effect on gastritis and gastric ulcer. Some patients’ symptoms will last longer, in the treatment can also consider the local excision, or the use of electrocautery treatment.