Fever with a sore throat is most likely a sign of an upper respiratory tract infection, most commonly tonsillitis. Oral examination may reveal red and swollen tonsils with purulent secretions. Common symptoms of upper respiratory tract infection are fever with sore throat, cough, weakness of limbs and headache. In contrast, tonsillitis is mainly caused by bacteria and secretions collecting in the tonsillar fossa. The common causative organisms are mainly streptococci and staphylococci, which need to be treated with antibiotics. In addition to severe pain in the throat, the patient may have a high fever (39°C to 40°C) and the tonsils may be enlarged or even suppurate on examination, along with congestion in the throat wall and enlarged lymph nodes in the lower jaw. For mild sore throat with fever, you can use some tablets, such as compound donglingcao tablets or compound grass coral tablets, watermelon cream tablets, etc. You can also take some antipyretic drugs, such as ibuprofen extended-release capsules or acetaminophen tablets. Gargling with salt water after three meals daily can have an antiseptic and anti-inflammatory effect. In short, fever with sore throat can be treated with some antipyretic and throat moistening drugs, while purulent tonsillitis is often caused by bacterial infection and requires antibiotics such as cephalosporin and penicillin.