Gallstones are a relatively common disease in life, mainly due to obesity, high-fat and high-sugar diet, mental tension and other factors. 2, infection: gallstones combined with chronic infection or acute infection, repeated attacks will stimulate the body’s immune system, the body’s immune system burden, long-term damage; 3, cholecystitis: gallbladder as an important organ of the digestive system, mainly used to store and concentrate bile, when there are gallstones in the gallbladder, it will lead to bile excretion function When there are gallstones in the gallbladder, it will lead to abnormal bile excretion function and gallbladder inflammation. In addition, if the stone is embedded, it may cause acute purulent cholecystitis and acute obstructive purulent cholangitis; 4, gallbladder cancer: if gallstones are not treated for long-term stimulation, it may increase the probability of gallbladder cancer. If gallbladder cancer occurs, it will seriously shorten the survival time; 5. Others: If critical illness occurs, it may cause great damage to the body, such as stones embedded in the opening of the pancreatic duct, causing acute pancreatitis, and also gallbladder duodenal fistula, liver abscess, biliary bleeding, etc. In daily life, patients with gallstones should be closely followed up and observed, and if there are relevant indications for treatment and surgery, they need to be treated early to avoid more serious damage to the body.