Side effects such as bruising, localized numbness and pain may occur with Botox wrinkle removal, and may also cause hazards such as stiff facial expressions and strabismus. If Botox wrinkle removal is performed with improper operation by medical personnel or improper care by the patient, side effects such as bruising, localized swelling and numbness, pain, mild nausea, immune-antibody reaction, and asymmetry of muscle activity may occur. Some patients may also experience hazards such as stiff facial expressions, strabismus, neck muscle weakness, and localized fibrosis. It is important to note that Botox wrinkle removal is not recommended for women who are allergic to Botox components, myasthenia gravis, multiple sclerosis, minors, pregnant as well as breastfeeding. Wrinkles do not affect human health, for people with beauty needs, it is recommended to go to a regular hospital to consult a doctor to understand the relevant matters, with the doctor standardized treatment.