Positive antinuclear antibody 1:1000 generally suggests the existence of immune diseases, it is recommended to consult the rheumatology and immunology department in a timely manner, under the guidance of the doctor to clarify the diagnosis and treatment as soon as possible. The normal value of anti-nuclear antibody in human body is less than 1:100, when anti-nuclear antibody shows 1:1000 strong positive, it is considered that the patient may suffer from idiopathic interstitial pulmonary fibrosis, rheumatoid arthritis, dry syndrome, polymyositis, dermatomyositis or scleroderma and other immune diseases. Antinuclear antibody positive 1:1000 need to go to the hospital in time to improve autoantibodies, blood sedimentation, C-reactive protein, muscle enzyme spectrum, liver and kidney function, blood and urine routine tests, etc., to clarify the cause of the disease according to the guidance of a professional doctor combined with personal circumstances, to take measures for targeted treatment, to avoid delayed aggravation of the symptoms of the disease and the adverse consequences.