Clinically Meige syndrome is easily misdiagnosed, often as myasthenia gravis, facial spasm, neurosis, delayed movement disorder, ophthalmologic disorders, etc. Therefore, attention should be paid to differentiate between: (1) myasthenia gravis. It has been reported in the literature that injection of neostigmine can reduce the symptoms of blepharospasm in some patients with Meige syndrome and misdiagnose them as myasthenia gravis. However, patients with myasthenia gravis not only have difficulty opening their eyes, but also have difficulty closing them tightly. They have no blepharospasm, can open their eyelids with their hands, and their symptoms are mild in the morning and severe in the evening. The symptoms are mild in the morning and severe in the evening, and are often combined with eye movement disorders. (2) Facial muscle spasm. The majority of facial muscle spasms are confined to one side, showing paroxysmal twitching of one facial muscle with short duration, occasionally involving both sides, but the bilateral spasms are not synchronized. In Meige’s syndrome, the eyelids are closed and difficult to open, while in Meige’s syndrome, some patients show only unilateral blepharospasm at the early stage of the disease, so it is important to distinguish it from facial myospasm. Three patients in this group were in this category. (3) Neurosis. Meige syndrome can occur at any age and is often associated with poor sleep, mood changes, fluctuating symptoms, and effective psychotherapy. Due to the serious impact on life, work and daily interactions. Patients are often depressed and are easily misdiagnosed as “hysteria”. (4) Delayed-onset movement disorder. It is usually caused by long-term oral antipsychotics or anti-Parkinson’s disease drugs, and the affected muscles are crepitant rather than spastic, and mainly the oral and lingual muscles, which can help diagnose based on the history of related diseases and medication. (5) Ophthalmic disease Because this disease is relatively rare, many ophthalmologists lack sufficient knowledge of this disease, and oculomotor Meige syndrome can easily be misdiagnosed as an ocular disease.