For a long time, there have been different views on the pathogenesis of neurasthenia, and there are debates: 1. The physiopathological view is that the essence of neurasthenia is the depletion of nerve cell energy, and the causative factors can be psychological and somatic, including “excessive” mental work. This view is represented by Pavlov’s experimental neurosis theory. It is believed that neurosis is caused by excessive tension between the excitatory and inhibitory processes of the cerebral cortex or by a conflict between the two processes. People of the neurological type are most susceptible to the disease. This is actually the continuation and development of Beard’s view. 2. The psychopathological view is that neurasthenia is a human reaction to focal emotions, and that somatic diseases and simple overexertion do not become the cause of neurasthenia, denying that there is cellular energy depletion. 3.Personality pathology viewpoint believes that neurasthenia is a special manifestation of personality disorder. Morita Masa’s neuroticism is the representative of this view. He believes that normal people overwork will produce fatigue and head discomfort after using the brain, but people with suspicious qualities produce misunderstandings, doubts and fears about this, and through mental interaction, these feelings are fixed to become neurasthenia.