Hepatitis C and hepatitis B are both chronic hepatitis diseases, hepatitis C is caused by hepatitis C virus infection, hepatitis B is caused by hepatitis B virus infection, the infection can lead to hepatitis, both have the tendency to progress to cirrhosis, liver cancer, so hepatitis C and hepatitis B two diseases are serious, both need timely treatment. The transmission of hepatitis B includes mother-to-child transmission, blood transmission and sexual transmission, while hepatitis C has three transmission routes like hepatitis B. However, the main transmission route is blood transmission, which is often seen in people who have frequent blood transfusions and hemodialysis, use non-disposable injection supplies, and use instruments that are not strictly sterilized. In terms of natural history, the onset of hepatitis C is very insidious, often without symptoms in the early stages, and patients generally do not show many symptoms of liver disease until they reach the serious stages of cirrhosis and liver cancer. In contrast, hepatitis B can show symptoms at an early stage, such as weakness, aversion to oil and grease, loss of appetite, jaundice and other manifestations, which will prompt patients to go to the hospital so that they can be treated as early as possible. From this aspect, hepatitis C is more serious because it starts insidiously and is usually at the stage of cirrhosis and liver cancer when it is discovered. From the treatment point of view, hepatitis C can be cured by 3 months of standard treatment, that is, the virus is cleared. In contrast, although there are many treatments for hepatitis B, it can only achieve the effect of viral suppression and cannot be cured. From this perspective, hepatitis B is more serious. Therefore, both hepatitis B and hepatitis C are serious and both have the possibility of progressing to cirrhosis, and it is important to protect yourself from hepatitis virus infection.