Recently, we have seen a number of children with coughs characterized by a long duration of illness, intense cough, and in some cases, spasmodic cough, which makes parents both anxious and distressed. Although a clear etiological diagnosis has not been made, it is important to be alert to Mycoplasma pneumoniae infection from its clinical presentation. Mycoplasma pneumoniae is a pathogen between virus and bacteria, and its incidence has been increasing in recent years. In addition to its clinical characteristics described above, it has the tendency to invade allergic individuals, is easily recurrent, has a long duration of illness, and may invade multiple organs. It also often has a tendency to become a small epidemic. Therefore, we need to pay some attention to it, to diagnose it in time, to treat it effectively and thoroughly, and to pay attention to the follow-up to prevent multiple organ damage.