High blood creatinine and low serum carbon dioxide can be seen after a lot of strenuous exercise and other physiological factors, usually after the removal of triggers can be returned to normal; can also be seen in pathological factors, such as acute and chronic renal failure, acute and chronic glomerulonephritis, membranous nephropathy, IgA nephropathy, lupus nephritis and other diseases, which usually suggests that the renal function is impaired. 1. Physiological factors: high blood creatinine, low serum carbon dioxide can be seen after a lot of strenuous exercise and muscular and other physiological factors, often without special treatment, usually after the removal of triggers can return to normal. 2. Pathological factors: can also be seen in acute and chronic renal failure, acute and chronic glomerulonephritis, membranous nephropathy, IgA nephropathy, lupus nephritis, diabetic nephropathy, hypertensive nephropathy, high uric acid renal damage and other diseases. When the patient’s kidney function is impaired, the glomerular filtration rate decreases and the water-electrolyte imbalance can lead to elevated blood creatinine and low serum carbon dioxide. At this time, timely medical treatment is needed. If you find high blood creatinine and low serum carbon dioxide, it is recommended to go to the hospital in time to find out the cause and follow the doctor’s instructions to standardize the treatment.