Dagliflozin and Glimepiride can generally be taken at the same time, but need to be used under the guidance of a doctor. 1. Dagliflozin: It is a new type of oral hypoglycemic drug, belonging to SGLT-2 inhibitor, which lowers blood glucose by inhibiting glucose reabsorption and promoting urinary glucose excretion. It is mainly applied to patients with type 2 diabetes mellitus, who may develop urinary tract infection. 2. Glimepiride: It belongs to the group of sulfonylurea drugs, through stimulating the pancreatic β-cells to secrete insulin to make blood glucose drop. It is mainly applied to patients with type 2 diabetes whose blood sugar control is unstable through diet and exercise therapy alone, and the main adverse reaction is hypoglycemia. Dagliflozin and glimepiride can generally be taken at the same time, but need to be used under the guidance of a doctor, not blindly self-medication. If there is any discomfort during the use of medication, consult a doctor in time to avoid delaying the condition.