The severity of the disease in patients with hepatitis B major tri-positive cannot simply look at the indicators of hepatitis B major tri-positive, but also in combination with whether abnormal liver function hepatitis B major tri-positive indicates significant viral replication, more infectious. And liver ultrasound situation. Positive hepatitis B surface antigen, e antigen and core antibodies are called major triplets. When the patient has a high DNA viral load but normal liver function, it is the immune tolerance period of hepatitis B. The virus has not damaged the liver cells or the damage is slight, and at this time, although there is a lot of virus, the disease is not serious and may be in an asymptomatic state. If the patient is a major triple-positive, but there is damage to liver function, such as high transaminases, and ultrasound shows enlargement of the liver or a large spleen, antiviral and liver-protective treatment is needed. The liver function should be monitored regularly, usually once every 3-6 months, and the patient should pay attention to rest, avoid overwork and anxiety, avoid unnecessary drugs, and avoid drinking alcohol.