Once people are missing the skull, the cranial cavity environment changes, intracranial pressure is not stable, then the cerebrospinal fluid circulation, blood circulation, neurological function of the cranium may be interfered with and affected, resulting in a series of cranial defect syndrome, jeopardizing the health of the body; there is also an important point is that, the cranial bone is missing, then the appearance of the changes are likely to occur, or is collapsed or puffed out, it is very unsightly, and many patients are also more concerned about this, may have some low self-esteem or depressed mood, which is also very scary. Many patients are more concerned about this, and may have some low self-esteem or depression, resulting in some psychological problems, which is also very scary. Therefore, cranial defects should be treated in a timely manner. Cranium has an important role for our health, so patients must choose advanced materials for cranial repair. As to whether the repair material needs to be replaced or not, strictly speaking it will not need to be replaced, but because the titanium mesh material may cause postoperative rejection infection, scalp abrasion, titanium mesh exposure and other situations, which will need to take out the material, and then repair it again after the treatment is recovered, so it is not recommended to use titanium mesh material for cranial bone repair. In recent years, we have been widely carrying out cranioplasty with polyether ether ketone peek material. This technique uses peek as the implant material and takes the embedded repair method, which has a very low rate of postoperative rejection and infection, and effectively avoids the exposure of the material. At the same time, we introduced the concept of plastic surgery, unique design of the material aperture, thickness, postoperative natural beauty, high comfort, strong protection. Warm reminder: cranial defect patients in the cranial bone repair, should at the outset to choose and autologous cranial bone is equivalent to the appropriate repair material, to avoid choosing the occurrence of rejection reaction of the slight material, again repair, resulting in secondary damage.