Diabetes can cause neuropathy. When diabetes affects the central nervous system, it can cause mental changes or ischemic stroke, accelerated brain aging, and Alzheimer’s disease. Damage to peripheral nerves can cause abnormal sensation due to distal sensory and motor nerve involvement in the hands and feet, pain hypersensitivity, and later loss of sensation with atrophy of small muscle groups, ataxia, and neurological arthropathy. In addition, some patients may develop autonomic neuropathy, such as delayed gastric emptying, diarrhea, constipation, accelerated heartbeat at rest, upright hypotension, myocardial ischemia, etc. Sudden cardiac death may occur in severe cases.