In most cases, thoracic malignant tumors involving the heart or aorta are sentenced to death by thoracic surgeons and are lost to surgery. Up to now, we and Prof. Jane Li from the Department of Thoracic Surgery have successfully performed 5 cases of such surgery. In three cases, the esophageal cancer involved the thoracic aorta, one case of lung cancer involved the left atrium, and one case of mediastinal tumor involved the right ventricle. The upper and lower ends of the aorta involved by the tumor were separated about 3 cm, the upper and lower arteries were cannulated, the thoracic aorta was blocked and a bypass shunt was performed. One patient had left-sided lung cancer involving the left atrium. The patient was placed in the right lateral position, and most of the lung cancer was separated, and the last part of the lung cancer was treated with adhesion to the heart. The patient was intubated through the ascending aorta and right atrium to establish extracorporeal circulation, and the left atrium was incised under parallel transfer machine, and the diseased atrium was excised and directly sutured to the left atrium. The tumor was heavily adhered to the right ventricle, and the right ventricle ruptured about 0.5 cm during the separation, which was closed with spacer prolene suture to stop the bleeding. The huge mediastinal tumor was completely removed under delicate operation. All patients were successfully discharged from the hospital. Close cooperation between cardiac and thoracic surgery can save the lives of some patients with malignant tumors of the chest involving the heart or aorta.