Cholinesterase is high mainly due to the following causes: 1, liver disease, specific types of disease, including viral hepatitis, fatty liver, cirrhosis, the liver is an important place for the decomposition and metabolism of cholinesterase, once the liver changes, the liver cell activity decreases, which will lead to its catabolic function is blocked, resulting in high cholinesterase. 2, organophosphorus poisoning, after the symptoms of organophosphorus poisoning, the human body out of the protection mechanism 3, other types of diseases, such as malnutrition, neurological damage, hyperthyroidism, the secretion of cholinesterase is related to the human nervous system, metabolic system, digestive system and other system tissues. For patients with high cholinesterase, further tests are needed to confirm the etiology.