Currently, cholinesterase is mainly used in the evaluation and analysis of organophosphorus pesticide poisoning and its liver function, as a reference for the severity of the disease and its prognosis. Clinically, low cholinesterase can be seen in patients with organophosphorus pesticide poisoning, liver cirrhosis, gastrointestinal bleeding, gastrointestinal tumor diseases, and even in patients with myocardial infarction, long-term starvation, etc. Cholinesterase is mainly synthesized and decomposed in the liver, and the decrease of cholinesterase is mostly caused by the abnormal metabolism of the liver, which indicates that the liver is damaged to different degrees, and the synthesis function of the liver decreases, resulting in the decrease of cholinesterase. Patients with organophosphorus poisoning have decreased cholinesterase activity, which leads to lower cholinesterase. The lower the cholinesterase enzyme indicates that the organophosphorus poisoning is more critical and needs to be rechecked daily.