Tracheal edema is usually seen in severe allergic reactions, such as penicillin allergy, and is a common clinical emergency that requires urgent resuscitation when it occurs. Common symptoms are dyspnea, cough, chest tightness, shortness of breath and a whistling sound while breathing, often accompanied by generalized edema and urticaria. Firstly, epinephrine and hormone treatment should be given immediately. Secondly, oxygen therapy should be given immediately and tracheal intubation or incision preparation should be done. Third, give other anti-allergy medications, such as fenagine and loratadine, etc. Fourth, monitor the changes in the patient’s condition and administer fluids to combat shock and other treatments.