As people age, the number of diseases they suffer from gradually increases. Some diseases such as cerebral infarction and coronary artery disease require long-term use of the drug aspirin. What about these patients who have gallbladder disease and need surgery? First of all, during the visit, in addition to the doctor’s medical history, the patient and family members should take the initiative to tell the doctor about the recent medications, especially anticoagulant drugs, such as warfarin and aspirin. Aspirin is a commonly used anticoagulant drug that inhibits platelet aggregation and prolongs bleeding time. Platelet aggregation is required to stop bleeding in both our internal and external wounds. After taking aspirin, the wound, especially the internal wound, may cause more bleeding and affect the patient’s life safety. For patients taking aspirin in the Department of General Surgery, Nanjing First Hospital, Liu Zijun, for elective gallbladder surgery, it is generally safer to stop the drug for 1 week after the surgery and choose general anesthesia for anesthesia. Because of lumbar anesthesia or epidural anesthesia, which is often referred to as hemi-anesthesia, there is a risk of paraplegia caused by compression of nerves by hematoma at the puncture site. For some acute and critically ill patients such as gallbladder perforation, it is safer to operate if it is possible to extend the time of drug withdrawal by more than 15 hours. Because the half-life of aspirin is 15-20 hours (half-life generally refers to the time required to reduce the maximum concentration of the drug in the plasma by half). We have found no serious bleeding in many acute gallbladder patients who have been off the drug for more than 15 hours, whether open surgery or laparoscopic surgery, and have recovered successfully. Of course, we also encountered a case of septic cholangitis, infectious shock taking aspirin, due to life-saving, emergency surgery, the patient stopped taking aspirin for a very short time, serious bleeding from the trauma during surgery, and then closed the abdomen after filling with gauze, after platelet transfusion and other treatment, the blood stopped after 2 days, and then discharged after the second surgery to remove the gauze, and healed. When to take aspirin after surgery, the authors believe that it can be taken generally 24 hours after surgery and will not cause intra-abdominal bleeding, which is also confirmed by our daily work. In the past, we have encountered very few cases of cerebral infarction in cholecystectomized patients who did not take aspirin after surgery and did not receive anticoagulant drugs such as low molecular heparin. Aspirin taken 24 hours after surgery had no effect on the healing of the laparoscopic puncture hole and had no effect on the healing of the open surgical incision in most cases. In the past, there was only one case of open cholecystectomy in which a small amount of bleeding from the incision occurred.