Viagra generally refers to Sildenafil, and in general, long-term use of Sildenafil may lead to kidney damage. Sildenafil is a kind of medication used clinically to treat erectile dysfunction disease in men. Occasional application of small amount generally will not cause damage to the kidneys, but long-term application of large amount of sildenafil may lead to kidney damage, and also lead to other adverse reactions and side effects. In addition, the adverse reactions of sildenafil include damage to the cardiovascular system, such as angina pectoris, hypotension, etc.; damage to the endocrine system, such as gout, diabetes mellitus, etc.; damage to the respiratory system, such as dyspnea, pharyngolaryngitis, etc.; and damage to the musculoskeletal system, such as arthritis and tenosynovitis. It also has damage to the urinary system, immune system, nervous system, gastrointestinal tract, eyes and so on. The drug is prohibited in combination with nitrate drugs, it is also contraindicated in women, people who are allergic to the product, children, people whose recent cardiovascular state does not allow them to have sex. The drug should be used under the supervision of a regular doctor.