There is no so-called “10 drugs” for the treatment of premature ovarian failure, which is currently incurable and is mainly symptom control, with hormone replacement therapy as the main drug treatment. Premature ovarian failure is a disease of diminished ovarian function, which can be characterized by irregular menstruation, fluctuating decline in estrogen levels, etc. The disease is usually incurable, but symptoms can be improved through active treatment. Hormone replacement therapy, including estrogen and progesterone, can improve symptoms and prevent osteoporosis and cardiovascular disease; phytoestrogens, including heterocyclic polyphenols, can also be used to improve symptoms of low estrogen. If the symptoms of premature ovarian failure occur, timely treatment can be carried out to improve the quality of life, and daily should be a balanced diet and pay attention to exercise.