【Overview】Choledocholithiasis is a stone located in the common bile duct, which can be divided into primary choledocholithiasis and secondary choledocholithiasis from the gallbladder according to its source. The clinical manifestations of common bile duct stones and the mild, severe and critical conditions depend entirely on the degree of stone obstruction and the presence or absence of biliary tract infection. Paroxysmal epigastric colic, chills and fever and jaundice at the onset (Charcot triad) are the typical manifestations of secondary biliary tract infection with stone obstruction. If the biliary tract infection is serious and complicated by acute obstructive septic cholangitis, the disease develops rapidly and nearly half of the patients soon develop irritability, delirium or drowsiness, coma and infectious shock manifestations such as decreased blood pressure and acidosis, which will lead to death if not treated in time. Treatment】The first choice is to remove the stone through endoscopic sphincter of Oddi, or surgical treatment for larger and harder stones that are difficult to remove endoscopically. Pre-operative preparation】Improve the relevant examination, sign the informed consent form, and understand in detail the purpose of this treatment, the possible complications and the treatment methods. Preoperative allergy test of contrast agent should be performed, and the patient should fast for 12 hours and 6 hours before the examination. Lidocaine syrup should be administered 5 minutes prior to the procedure. Valium can be given intramuscularly and 654-2 intramuscularly before the operation. Postoperative treatment】Postoperatively, the patient should be fasted with water, and should be gradually transitioned from liquid food to semi-liquid food after feeding. After surgery, blood amylase should be checked urgently and again the next morning. And give rehydration, application of enzyme-suppressing and acid-suppressing drugs, and closely observe the occurrence of bleeding and pancreatitis, such as: fever, abdominal pain, vomiting blood, blood in stool, etc.