Hepatitis B immunoglobulin (HBIg) is an exogenous antibody to prevent hepatitis B virus infection. It is an immune preparation that can be injected into the body to make people receive this antibody and quickly obtain high-valent protective immunity, which can rapidly clear the free hepatitis B virus in the serum in a short period of time, prevent further spread of infection and regulate immunity. Due to the different origins of hepatitis B immunoglobulin, the price is not consistent, the price of imported ones is higher, more than 1000 yuan, and domestic ones are mostly between 300-350 yuan, and the dose is 200IU2ml/pc. Hepatitis B immunoglobulin is extracted from the plasma of healthy blood donors. Generally, there is a high titer of hepatitis B surface antibody in the plasma of healthy blood donors, which can form high-valence hepatitis B immunoglobulin after concentration. The price of immunoglobulin is becoming more and more expensive due to the decreasing number of blood donors and the tight control of the price of blood products by the state, resulting in an oversupply. There are two main uses of hepatitis B immunoglobulin: (1) to interrupt mother-to-child transmission of hepatitis B, for pregnant women with positive hepatitis B surface antigen; (2) to prevent and prevent further spread of infection, for susceptible persons with risk of HBV infection, such as doctors, nurses and laboratory personnel. To sum up, hepatitis B immunoglobulin is an immune preparation used to prevent hepatitis B virus infection. The price varies depending on the manufacturer, but it is usually used only temporarily and cannot obtain long-lasting immunity.