Today, we met a 16-year-old boy with abnormal breast development, his father brought him to the clinic, because the abnormal breast development of the child, resulting in the child’s low self-esteem afraid to go bare-chested, when bathing also afraid to go to the public bath, has been avoiding his family, but his father accidentally found the child’s abnormal, today brought him to the clinic, after understanding the condition of the child to do ideological work, told him that this is puberty hormone He told him that this was an abnormal secretion of hormones during puberty, and that it could be cured by itself after a period of time. Now I would like to give you some basic information about abnormal breast development during puberty in children: Male pubertal breast development refers to the enlargement of one or both mammary glands caused by benign hyperplasia of the breast tissue in males during youthful development. It usually occurs between the ages of 12 and 16, and the enlarged breast tissue is usually no more than 3 cm, may be asymmetrical and mildly painful to the touch, and mostly lasts 12 to 18 months, gradually shrinking to disappear with the maturation of male sexual development, or it may last 2 to 3 years or even persist for a long time. Etiology: Male pubertal breast development is generally believed to be caused by a transient imbalance between estrogen and androgen during puberty, with estrogen reaching adulthood levels first and androgens reaching adulthood levels later. However, the following diseases need to be identified: 1. Testicular tumors and feminized adrenal cortical tumors Patients may have gynecomastia. This is due to excessive estrogen production in the tumor tissue and enhanced aromatization of the surrounding tissue. Hypogonadism and androgen insensitivity syndromes are associated with gynecomastia due to congenital abnormalities or defects in testosterone biosynthesis enzymes and abnormal testicular function due to infection, chemotherapy, and trauma. One of the important etiologies is Creutzfeldt-Jakob syndrome. 3, extra-gonadal tissue aromatization of estrogen precursors is enhanced It can be seen in a variety of diseases, such as obesity, liver disease, hyperthyroidism, etc. 4, drug factors such as androgens, anabolic steroids, estrogens, ketoconazole, etc.