High-grade invasive bladder cancer is a pathological type of bladder cancer. Most bladder cancers are malignant bladder tumors, including non-invasive bladder cancer and invasive bladder cancer. Non-invasive bladder cancer refers to cancer confined to the mucosal layer and not invaded to the muscular layer; invasive bladder cancer refers to tumor penetrating the mucosal layer of bladder and infiltrating to the muscular layer. High-grade invasive bladder cancer refers to tumor with higher malignancy, whose cell division ability, regeneration ability and metastasis ability are stronger. Generally, the surgical treatment plan is determined according to the patient’s local and systemic conditions.