The traditional treatment of diabetic foot includes medication, wound replacement and surgery. In recent years, with the maturity of endoluminal vascular technology, percutaneous transluminal angioplasty and endovascular stenting have become more and more the first treatment for diabetic foot vascular lesions, with safety and efficacy recognized by more and more experts, and its advantages of minimally invasive and multiple interventions in stages are incomparable to traditional surgery. Endoluminal vascular technology, in simple terms, is a catheter that is inserted into the lower extremity blood vessels to reveal vascular lesions such as stenosis, occlusion, thromboembolism, etc. through imaging, and treats diabetic vascular lesions through balloon dilation technology, stent support technology, and infusion of thrombolytic drugs through the catheter. Our interventional department has many years of clinical experience in the application of endoluminal vascular technology in the treatment of diabetic foot, which has saved the majority of diabetic foot patients from the pain of foot pain and amputation. In addition, our department is actively exploring new means and techniques for the treatment of diabetic foot. At present, we use patients’ autologous stem cells, which are aseptically cultured into vascular endothelial precursor cells in vitro and injected directly into the diseased vascular site through intravitreal technology to remodel the vascular endothelium damaged by hyperglycemia and inflammatory mediators, making the vascular endothelium smooth and smooth as new. This technology is in the stage of animal testing and will be applied to clinical treatment after verification by rigorous clinical experiments and FDA approval, bringing gospel to the majority of patients.