If the 4D examination is not passed, amniocentesis is needed, and the specific situation needs to listen to the doctor’s advice. Four-dimensional examination belongs to the examination of malformation, if the four-dimensional examination did not pass, it may be that the fetus has problems with the structure of the organs, and the patient needs to further do non-invasive DNA, or even amniocentesis to determine whether the fetus has chromosomal and other malformations; or it may be due to the pregnant woman’s own abdominal wall is relatively obese or the fetus fetal position is incorrect, and it is necessary for the patient to carry out the examination for a number of times. Amniocentesis is a karyotyping analysis of amniotic fluid cells, gene and gene product testing, which can clarify whether the fetus is suffering from chromosomal disorders or malformations. If through the maternity test, found that the Down’s syndrome screening results of high risk, indicating that the fetus suffers from chromosomal diseases than the chances of larger, need to further do amniocentesis test to confirm the diagnosis. Pregnant women who have not had a 4D can move around more, strengthen their diet and nutrition, have regular checkups, and listen to the doctor’s advice.