Flatulence on an empty stomach can be caused by irritable bowel syndrome, gastritis, enteritis, indigestion and other causes. 1. Irritable bowel syndrome: irregular diet or emotional factors may cause gastrointestinal tract dysfunction, manifested by abdominal distension and other uncomfortable symptoms, which can be manifested as flatulence on an empty stomach. 2. Gastritis: Gastritis caused by various reasons may result in abnormal secretion of digestive juices in the gastrointestinal tract and slowing down of gastrointestinal peristalsis, which may also lead to flatulence on an empty stomach. 3. Enteritis: the intestinal tract is infected by external pathogenic bacteria, or under the influence of cold and other factors, may also cause an inflammatory reaction, which can lead to the symptoms of flatulence on an empty stomach. 4. Indigestion: Due to various reasons, patients may have obstacles in food digestion and absorption, and suffer from bloating and abdominal discomfort, etc. They need to have a balanced diet, reduce spicy and stimulating foods, quit smoking and drinking, and exercise moderately. Patients with bloating as the main symptom can use some gastrointestinal prokinetic drugs such as domperidone. There may be other causes of abdominal bloating on an empty stomach, and it is necessary to go to the hospital for further examination to determine the cause of the problem and follow the doctor’s instructions.