The symptoms of stomach cramps in the middle of the night are mainly considered to be the manifestation of acute gastroenteritis. Patients with acute gastroenteritis disease after the stomach, intestines and other digestive organs and tissues of the smooth muscle will appear violent contraction and spasm phenomenon, which leads to the patient abdominal symptoms of severe pain. In addition, acute gastroenteritis patients are often accompanied by diarrhea, fever, fatigue and other adverse manifestations. For this kind of disease you can use broad-spectrum antibiotic drugs for anti-infection treatment, such as cefradine, furacilin, roxithromycin and so on. But appendicitis, colon polyps, intestinal mucosal neurofibroma and other types of diseases, can also cause the appearance of such adverse symptoms. So you need to go to the hospital for relevant examinations, such as abdominal CT examination, ultrasound examination, stool routine and so on, in order to confirm the diagnosis and treatment.