Sleeplessness throughout the night is the clinical manifestation of insomnia and is the most common sleep disorder. Insomnia is a subjective experience of decreased sleep quality and duration due to difficulty falling asleep or sleeping continuously, which cannot meet the needs of normal physiological and physical recovery and affects normal social function. Sleeplessness throughout the night is a serious insomnia. The main causes of insomnia are as follows: 1, genetic factors: the incidence of insomnia in people with a family history of insomnia is three times that of those without a family history; moreover, the incidence of insomnia increases gradually with age, especially in older women; 2, psychological factors: life, work and other environmental impact on emotions, excessive daily pressure, resulting in depressed mood, high expectations of sleep can not sleep leading to mental tension, etc., which can lead to sleep These can lead to a decline in the quality of sleep or even insomnia. 3, life factors: sleep environment change or sleep posture error, drinking a lot of coffee, tea or energy drinks during the day, too full or hungry before going to bed, etc., these are factors that are not conducive to sleep. 4, somatic diseases: insomnia may be the clinical manifestation of certain diseases, such as depression, somatoform disorders, restless legs syndrome, etc.; in addition, the concomitant symptoms of Parkinson’s disease, peripheral neuropathy and other diseases can also lead to insomnia, and some people who take hormones and stimulant-containing drugs can also have insomnia performance. In summary, insomnia is caused by a variety of complex factors, including physiological, psychological, environmental, drug and other factors of change, long-term all-night sleeplessness will seriously endanger health, but as long as the cause is found and treated for the cause, but also to be alert to the presence of somatic diseases caused by secondary insomnia.