The clinical significance of the five hepatitis B items Many patients and family members often take the five hepatitis B test sheets to consult their doctors, so how exactly should the five hepatitis B items be read? The five items of hepatitis B include surface antigen (HBsAg), surface antibody (anti-HBs), е antigen (HBeAg), е antibody (anti-HBe), core antibody (anti-HBc) and other five items. I. HBsAg: HBsAg is the shell protein of the hepatitis B virus, which itself is not infectious, and its appearance is often accompanied by the presence of the hepatitis B virus, so it is a sign of having been infected with the hepatitis B virus. HBsAb: Hepatitis B virus invades the body will stimulate the human immune system to produce an immune response, the human immune system in the B lymphocyte secretion of a specific immunoglobulin G. It can be specifically combined with the surface antigen, in the body and the body’s other immune function together, the virus can be removed, to protect the body from further infection by the hepatitis B virus, so called surface antibodies for protective antibodies Therefore, surface antibodies are called protective antibodies. When hepatitis B surface antibody is positive, the body has resistance to the hepatitis B virus, the higher the level of positive surface antibody, the stronger the resistance. HBeAg: HBeAg originates from the core of hepatitis B virus and is a subcomponent of core antigen or a product of core antigen cleavage. e antigen is a soluble protein. The HBeAg is a measure of the infectiousness of hepatitis B. HBsAg, HBeAg, HBcAb three positive is what we usually call the “big three”, when the patient is highly infectious. The three positives of HBsAg, HBeAb, and HBcAb are what we usually call the minor triplets. Five, HBcAb: core antigen can stimulate the body’s immune system to produce specific antibodies HBcAb, through the detection of HBcAb can understand whether the body has had the stimulation of core antigen, that is, whether there has been hepatitis B virus infection. It is important to note that some patients are HBcAb positive and other indicators are negative, such patients need to be quantified for hepatitis B virus to determine whether they are “occult hepatitis B”.