Mycoplasma infections are generally categorized into Mycoplasma pneumoniae infection and Mycoplasma genitalium infection. However, there is no clear data indicating the duration of medication for Mycoplasma genitalium infection. Usually patients with Mycoplasma pneumoniae infection need to follow the doctor’s instructions to use erythromycin, roxithromycin and other antibiotic drugs, if the patient is not sensitive to macrolides, you can also use levofloxacin, moxifloxacin and other antibiotics, the course of its treatment is usually in 2~3 weeks. As for the medication course of Mycoplasma genitalium infection, there is no clear clinical data. However, most women can clear Mycoplasma genitalium infection within 6 months, and a small number of patients may last about 1 year. Patients need to choose a reasonable course of medication according to their own situation and under the guidance of their doctors. It is recommended that patients with mycoplasma infections seek medical attention in a timely manner and follow the doctor’s instructions for targeted treatment according to the extent of their condition and choose a reasonable course of medication.