The probability of benign laryngeal biopsy is mainly related to the nature and characteristics of the mass, as well as the doctor taking the material and other factors, mainly the following analysis: 1. If the laryngeal mass itself is benign, the probability of taking a biopsy benign is one hundred percent. For example, some patients are vocal cord polyps, in this case the probability of taking a biopsy benign is 100 percent. In the case of junctional tumors, such as leukoplakia or papilloma, the biopsy may be benign or locally malignant. In some patients with vocal cord cancer or hypopharyngeal cancer, laryngeal cancer and other related diseases, the examined mass itself is ulcerative growth, cauliflower growth, with very unsmooth surface and lymph node metastasis in the neck, etc. In such cases, the probability of taking biopsy for benign is very low, and under normal circumstances, taking biopsy can find locally diseased tissues. 2. The probability of taking biopsy for benign is related to the material taken by doctors, Some patients have laryngeal cancer, hypopharyngeal cancer, but the cancer surface has ulceration, erosion or inflammatory changes such as edema. If the doctor does not take the material deep enough or takes less material, it may appear as a benign lesion, but in fact it is a malignant tumor, which can be easily misdiagnosed. In conclusion, the probability of benign laryngeal biopsy is related to the nature of the lesion itself as well as the physician’s sampling and other factors.