Itchy hands and feet at night can be caused by body sensitivity, low cortisol hormone levels, mental factors. 1. Sensitive body: sensitive body can be induced by external triggers such as itchy hands and feet, itchy symptoms during the day is not obvious, when the night when the nerve excitation, can stimulate the nerve and lead to itchy hands and feet symptoms. 2. Low level of cortisol hormone: cortisol hormone can play a role in protecting the body, high level of secretion of cortisol hormone during the day, may not be uncomfortable symptoms, the night when the hormone secretion level is lowered, the protective effect of the weakening of the itchy hands and feet can be caused by the situation. 3. Mental factors: daily life and work pressure, can lead to mental instability, easy to nervousness, anxiety, depression and other negative emotions, in the night time can be triggered by the symptoms of itching hands and feet. It is recommended that patients with itchy hands and feet at night should consult a doctor in a timely manner to clarify the cause and follow the doctor’s instructions to standardize the treatment, which will help alleviate the discomfort.