Most laxatives have varying degrees of toxic effects and side effects, and long-term use may result in the following: (1) they can stimulate the digestive tract and cause nausea, vomiting, abdominal pain, etc.; (2) some laxatives, such as mannitol, which is a hypertonic laxative, can draw a large amount of water from the intestinal wall tissue and cause dehydration. (3) Abuse of laxatives during pregnancy, especially in the second trimester, may lead to miscarriage. (4) A small number of patients may develop allergic reactions, such as rash, allergic enteritis, etc. (5) Long-term use can also reduce the stress of the nerve receptor cells in the intestinal wall, and even if there is enough stool in the intestine, it cannot produce normal peristalsis and defecation reflex, thus making constipation more difficult to treat. (6) Long-term use of senna, rhubarb, aloe vera and other irritating laxatives can lead to colonic melanosis.