Many patients with chronic hepatitis B do not pay much attention to their disease and do not have regular checkups, thinking that the disease does not develop so rapidly or that there is no problem if there are no symptoms. Some people, even if the review, only check the liver function to see whether it is normal or not, and do not take the other tests suggested by the doctor seriously. In fact, this is a wrong understanding. There are also some patients who can’t even distinguish between liver function and hepatitis B DNA quantitative test, thinking that checking liver function can tell the viral load or whether there is cirrhosis. Therefore, it is necessary for patients with chronic hepatitis B to understand the significance and role of the relevant tests. 1, liver function Liver function includes a number of indicators such as alanine aminotransferase, glutamate aminotransferase, glutamyltranspeptidase, alkaline phosphatase, cholinesterase, albumin, prealbumin, total bilirubin, total bile acid and so on. Among them, alanine aminotransferase and glutamine aminotransferase reflect the severity of hepatocellular necrosis and liver parenchymal damage. Total bilirubin, glutamyl transpeptidase and alkaline phosphatase reflect liver metabolism and cholestasis. Albumin, prealbumin, and cholinesterase reflect the synthesizing function of the liver. Sometimes normal aminotransferase does not mean normal transpeptidase, etc. Therefore, we still recommend patients with chronic hepatitis B to check the major liver function instead of minor liver function. HBV-DNA Hepatitis B DNA quantitative examination directly reflects the state of hepatitis B virus replication and the strength of infectiousness, which can be used to observe the effect of antiviral treatment and guide the selection of antiviral drugs. Some patients are puzzled by the difference between hepatitis B five and HBV-DNA, in fact, hepatitis B five reflects whether there is virus or antibody, and does not reflect the amount of virus. 3, ultrasound ultrasound intuitively responds to the morphological changes of the liver, showing the size of the liver, whether there is damage, cirrhosis or portal hypertension, whether there are stones, cysts or occupancy and so on. It can effectively monitor the morphological changes of the liver. Liver elastography Liver elastography is used to assess the degree of liver fibrosis by measuring the stiffness of the liver through a transient elastography technique. This test is a non-invasive, painless, rapid, simple and objective quantitative detection of liver fibrosis. Liver elastography utilizes ultrasound technology to assess the hardness of the liver through the elasticity value of liver tissues reflecting on low-frequency ultrasound vibration waves, the larger the elasticity value, the harder the liver tissue is and the more serious the degree of fibrosis. Liver fibrosis is a dynamic process of damage and repair, and the development of liver fibrosis cannot be detected by a single liver puncture. Compared with multiple liver punctures to detect the development of liver fibrosis, liver elasticity measurement is undoubtedly more advantageous with its non-invasive and convenient. 5, Coagulation four The liver is an important place for the synthesis of many kinds of coagulation factors, and also a place for the synthesis of fibrinolytic enzymes. When liver disease occurs, due to the decrease or depletion of coagulation factor synthesis, and the generation or increase of anticoagulant substances, the coagulation mechanism is often caused by abnormal changes. As a result, some patients often have mild bleeding when brushing teeth, or have difficulty in stopping bleeding when bleeding occurs due to trauma. The coagulation four effective response to the normal or not of the coagulation mechanism, from a certain degree reflects the progress of liver disease. 6, blood routine Many patients with chronic hepatitis B do not understand what can be found in blood routine, and think that it is completely superfluous to review blood routine without any significance. This idea is incorrect. Routine blood test is a basic examination for patients with chronic hepatitis B, because the liver has certain functions of hematopoiesis, blood storage and regulation of circulating blood volume, so it can react to the hematopoiesis and blood circulation of the liver, and at the same time, it can also indicate whether there is splenic hyperfunction, whether there is any complication of bacterial infections, and it can even find the early signs of many systemic diseases. For patients with chronic hepatitis B treated with interferon, it is more important to review the blood routine regularly because interferon can inhibit the bone marrow image and lower the white blood cells. By reviewing the routine blood test, it can further guide the interferon treatment. Alpha-fetoprotein Alpha-fetoprotein is generally used as a diagnostic index of primary liver cancer, which is of great value in determining the condition and prognosis of liver cancer. Therefore, for chronic hepatitis B patients with more than ten years of medical history, especially men over 40 years old, the examination of alpha-fetoprotein is very important. It is important to try to achieve early detection and early treatment so as not to miss the best time. The above tests, usually half a year to a year review can be. Only through regular review can we monitor the development of the disease as much as possible, so as to get the best treatment timing and treatment effect.