There is no effective oral medication for puborectal muscle spasm, and common treatments include anal dilation, local injection of botulinum toxin type A, and surgery. Puborectal muscle spasm is medically known as puborectalis syndrome, a spastic hypertrophy of the puborectalis muscle, resulting in obstruction of the pelvic floor outlet, causing defecation obstruction. It may be related to chronic inflammation around the anal canal, laxative abuse and pelvic floor muscle spasm. It manifests as difficulty in defecation and incomplete defecation. Its treatment includes: 1. Progressive anal canal dilatation: using three sizes of dilators, the patient is subjected to progressive anal canal dilatation every day, from small to large, each dilatation lasts for 10 minutes for a period of 3 months. 2. Local injection of botulinum toxin type A: the toxin can paralyze the innervated skeletal muscles, resulting in flaccid paralysis and paralysis, counteracting and relieving muscle spasms, so that the force between the muscles reaches a new balance, which can improve the symptoms of spasm of puborectal muscle. 3. Partial excision of puborectalis muscle: If there are pathological changes in puborectalis muscle, such as hypertrophy, inflammatory hyperplasia causing anal canal stenosis, then surgical treatment such as partial excision of puborectalis muscle is needed. Puborectal muscle spasm is generally no effective oral medication, there are other treatments for this disease, such as biofeedback training therapy, it is recommended to go to the hospital in a timely manner, under the guidance of a professional doctor, choose the appropriate treatment method, and comply with the doctor’s instructions.