There are various reasons for the non-healing of middle finger fissure, which may be related to wound infection, poor local blood circulation, poor local external environment and fixation, systemic factors and so on. 1. Wound factors: wound infection, wound wetness and exudate, tissue edema and so on. 2. Poor local blood circulation: good local blood circulation is conducive to the absorption of necrotic material and infection control; poor blood circulation may delay wound healing. 3. Poor local external environment and immobilization: excessive friction and pressure on the wound and its periphery may cause repeated injuries. 4. Systemic factors: These include advanced age, nutritional status, co-morbidities with chronic diseases such as diabetes mellitus, impaired immune system, impaired coagulation mechanism, neurological system, and individual psychological status. It is recommended that patients with hard-to-heal wounds go to regular hospitals for timely examination, to clarify the cause of the disease and to standardize the treatment reasonably.