Gray nail is a common fungal disease caused by fungal infection of the nail plate and the nail tissue. In clinical treatment, continuous therapy and intermittent shock therapy can be applied for oral antifungal treatment. However, patients should be aware that oral antifungal drugs are not used alone in the treatment of gray nails. Oral antifungal medications are used as a synergistic treatment with topical antifungal medications to enhance the patient’s effectiveness in treating the fungus. For example, itraconazole, which is commonly used in clinical practice, can be taken at 200mg per day, either continuously or twice a day at 200mg, discontinued for three weeks after a week, and then re-taken from the next month.