Cross-groove spinning of the nail is a typical symptom of Kawasaki disease (KD), a vasculitis syndrome of unknown etiology, with a high incidence in young children. It was first identified in Japan in 1961 and first reported in 1967, but the cause is still unknown. Kawasaki disease occurs in children under 5 years of age, and its incidence is increasing every year, replacing rheumatic fever as the leading cause of acquired heart disease in children in China and some Western countries. The disease is a vasculitis syndrome with the most severe damage to the cardiovascular system, with marked regional and ethnic differences. This syndrome is one of the leading causes of acquired heart disease in children and its incidence exceeds that of rheumatic heart disease. Then it is more important for us to actively learn about the prevention of this disease. 1. the replication of live viral vaccines blocked by gammaglobulin and the establishment of acquired immunity; 2. the safety of children recovering from Kawasaki disease after receiving live or other vaccines. Some autoimmune diseases, including systemic vasculitis, may deteriorate abruptly after the application of live or dead vaccines, so full vaccination after Kawasaki disease is delayed for at least 3 months (generally recommended after 6 months), and it is recommended that non-intestinal live viral vaccinations (measles, mumps, and rubella) should be delayed for at least 5 months after gammaglobulin (generally recommended after 6 months), because passive immune antibodies may interfere with the immune function of the immunizing agent. However, during measles outbreaks, measles vaccine should be applied early with caution to children who have not been previously passively immunized, and the vaccine should be repeated later.