Osteolysis, also known as osteolysis, is also known as ghost bone. It is a slowly developing and very destructive disease that manifests as spontaneous bone resorption and is a rare disease. It is characterized by massive localized capillary sinus and fibrous tissue proliferation in bone with osteolysis. There are more male patients than female. Symptomatology: The most common sites are the scapula, clavicle, humerus, thoracic spine and rib cage. The second is seen in the pelvis, thoracic and lumbar spine, and also in the humerus. It is less common in the ulna, radius, wrist and metacarpal bones, and less common in the tibia, fibula and toe bones, and sometimes in the upper and lower jaws. Etiology: It may be related to heredity, trauma, infection, hemangioma or lymphoma. The basic pathological changes are the proliferation of abnormal capillaries and lymphatic vessels and the proliferation of fibrous tissue leading to the dissolution of the adjacent bone tissue. Sometimes small foci of necrosis and lymphocytic infiltration with osteolysis are seen, often misdiagnosed as tumors, pathological fractures, celiac disease, and chronic osteomyelitis. The lesion starts in one bone and may cross over the surrounding soft tissue to invade adjacent bones. It is more common in males than females, with a male to female ratio of about 2:1. It can occur from infancy to old age, but is more common in adolescents.